Controlled Biologics and Materials

The following list of chemicals and mixtures are considered export controlled and will require a license from the federal government to be exported to any country.

Please Note: This list is not exhaustive and certain chemicals or mixtures, or medical, analytical, diagnostic, and food testing kits, can be considered export controlled for any country, even if they are not enumerated on this list.

Chemicals and mixtures in which at least one of the following chemicals constitutes at least 10% or more of the weight of the mixture:

• (C.A.S. #7784–34–1) Arsenic trichloride;
• (C.A.S. #76–93–7) Benzilic acid;
• (C.A.S. #78–38–6) Diethyl ethylphosphonate;
• (C.A.S. #683–08–9) Diethyl methylphosphonate;
• (C.A.S. #15715–41–0) Diethyl methylphosphonite;
• (C.A.S. #2404–03–7) Diethyl-N,Ndimethylphosphoroamidate;
• (C.A.S. #41480–75–5) N,NDiisopropylaminoethanethiol hydrochloride;
• (C.A.S. #5842–07–9) N,N-Diisopropylbeta-aminoethane thiol;
• (C.A.S. #96–80–0) N,N-Diisopropylbeta-aminoethanol;
• (C.A.S. #96–79–7), N,N-Diisopropylbeta-aminoethyl chloride;
• (C.A.S. #4261–68–1) N,NDiisopropyl-beta-aminoethyl chloride hydrochloride;
• (C.A.S. #6163–75–3) Dimethyl ethylphosphonate;
• (C.A.S. #756–79–6) Dimethyl methylphosphonate;
• (C.A.S. #677–43–0) N,Ndimethylamino-phosphoryl dichloride;
• (C.A.S. #1498–40–4) Ethyl phosphonous dichloride [Ethylphosphinyl dichloride];
• (C.A.S. #430–78–4) Ethyl phosphonus difluoride [Ethylphosphinyl difluoride];
• (C.A.S. #1066–50–8) Ethyl phosphonyl dichloride;
• (C.A.S. #993–13–5) Methylphosphonic acid;
• (C.A.S. #676–98–2) Methylphosphonothioic dichloride;
• (C.A.S. #464–07–3) Pinacolyl alcohol;
• (C.A.S. #1619–34–7) 3-Quinuclidinol;
• (C.A.S. #111–48–8) Thiodiglycol.
• (C.A.S. #762–04–9) Diethyl phosphite;
• (C.A.S. #868–85–9) Dimethyl phosphite (dimethyl hydrogenphosphite);
• (C.A.S. #139–87–7) Ethyldiethanolamine;
• (C.A.S. #10025–87–3) Phosphorus oxychloride;
• (C.A.S. #7719–12–2) Phosphorus trichloride;
• (C.A.S. #10545–99–0) Sulfur dichloride;
• (C.A.S. #10025–67–9) Sulfur monochloride;
• (C.A.S. #7719–09–7) Thionyl chloride;
• (C.A.S. #102–71–6) Triethanolamine;
• (C.A.S. #122–52–1) Triethyl phosphite;
• (C.A.S. #121–45–9) Trimethyl phosphite.
• (C.A.S. #1341–49–7) Ammonium hydrogen fluoride;
• (C.A.S. #107–07–3) 2-Chloroethanol;
• (C.A.S. #109–89–7) Diethylamine;
• (C.A.S. #100–37–8) N,NDiethylaminoethanol;
• (C.A.S. #589–57–1) Diethyl chlorophosphite;
• (C.A.S. #298–06–6) O,O-Diethyl phosphorodithioate;
• (C.A.S. #2465–65–8) O,O-Diethyl phosphorothioate;
• (C.A.S. #108–18–9) Di-isopropylamine;
• (C.A.S. #124–40–3) Dimethylamine;
• (C.A.S. #506–59–2) Dimethylamine hydrochloride;
• (C.A.S. #762–77–6) Ethyl chlorofluorophosphate;
• (C.A.S. #1498–51–7) Ethyl dichlorophosphate;
• (C.A.S. #460–52–6) Ethyl difluorophosphate;
• (C.A.S. #7664–39–3) Hydrogen fluoride;
• (C.A.S. #3554–74–3) 3-Hydroxyl-1-methylpiperidine;
• (C.A.S. #76–89–1) Methyl benzilate;
• (C.A.S. #754–01–8) Methyl chlorofluorophosphate;
• (C.A.S. #677–24–7) Methyl dichlorophosphate;
• (C.A.S. #22382–13–4) Methyl difluorophosphate;
• (C.A.S. #14277–06–6) N,N Diethylacetamidine;
• (C.A.S. #53510–30–8) N,N Diethylbutanamidine;
• (C.A.S. #90324–67–7) N,N Diethylformamidine;
• (C.A.S. #1342789–47–2) N,N Diethylisobutanamidine;
• (C.A.S. #84764–73–8) N,N Diethylpropanamidine;
• (C.A.S. #1315467–17–4) N,N Diisopropylbutanamidine;
• (C.A.S. #857522–08–8) N,N Diisopropylformamidine;
• (C.A.S. #2909–14–0) N,N Dimethylacetamidine;
• (C.A.S. #1340437–35–5) N,N Dimethylbutanamidine;
• (C.A.S. #44205–42–7) N,N Dimethylformamidine;
• (C.A.S. #321881–25–8) N,N Dimethylisobutanamidine;
• (C.A.S. #56776–14–8) N,N Dimethylpropanamidine;
• (C.A.S. #1339586–99–0) N,N Dipropylacetamidine;
• (C.A.S. #1342422–35–8) N,N Dipropylbutanamidine;
• (C.A.S. #48044–20–8) N,N Dipropylformamidine;
• (C.A.S. #1342700–45–1) N,N Dipropylisobutanamidine;
• (C.A.S. #1341496–89–6) N,N Dipropylpropanamidine;
• (C.A.S. #1314–80–3) Phosphorus pentasulfide;
• (C.A.S. #75–97–8) Pinacolone;
• (C.A.S. #7789–29–9) Potassium bifluoride;
• (C.A.S. #151–50–8) Potassium cyanide;
• (C.A.S. #7789–23–3) Potassium fluoride;
• (C.A.S. #3731–38–2) 3-Quinuclidone;
• (C.A.S. #1333–83–1) Sodium bifluoride;
• (C.A.S. #143–33–9) Sodium cyanide;
• (C.A.S. #7681–49–4) Sodium fluoride;
• (C.A.S. #16893–85–9) Sodium hexafluorosilicate;
• (C.A.S. #1313–82–2) Sodium sulfide;
• (C.A.S. #637–39–8) Triethanolamine hydrochloride;
• (C.A.S. #116–17–6) Tri-isopropyl phosphite.

Chemical Weapons Convention (CWC) Schedule 2 and families of chemicals

• (C.A.S. #382-21-8) 1,1,3,3,3-Pentafluoro-2-(trifluoromethyl)-1-propene (PFIB) and mixtures in which PFIB constitutes more than 1% of the mixtures weight;
• Precursor chemicals and mixtures in which at least one of the following precursor chemicals constitutes more than 10% of the weight of the mixture:
  • CWC Schedule 2 chemicals containing a phosphorus atom to which is bonded one methyl, ethyl, or propyl (normal or iso) group but not further carbon atoms;
  • N,N-Dialkyl (Me, Et, n-Pr or i-Pr) phosphoramidic dihalides;
  • Dialkyl (Me, Et, n-Pr or iPr) N,N-dialkyl (Me, Et, n-Pr, or i-Pr)-phosphoramidates;
  • N,N-Dialkyl (Me, Et, n-Pr or i-Pr) aminoethyl-2- chlorides and corresponding protonated salts;
  • N,N-Dialkyl (Me, Et, n-Pr or i-Pr) aminoethane-2- ols and corresponding protonated salts;
  • N,N-Dialkyl (Me, Et, n-Pr or i-Pr) aminoethane-2- thiols and corresponding protonated salts.

Chemical Weapons Convention (CWC) Schedule 3 and families of chemicals

• Toxic chemicals and mixtures in which at least one of the following toxic chemicals constitutes 30% or more of the weight of the mixture:
  • (C.A.S. #75–44–5) Phosgene: Carbonyl dichloride;
  • (C.A.S. #506–77–4) Cyanogen chloride;
  • (C.A.S. #74–90–8) Hydrogen cyanide;
  • (C.A.S. #76–06–2) Chloropicrin: Trichloronitromethane.
• Precursor chemicals and mixtures in which at least one of the following precursor chemicals constitutes 30% or more of the weight of the mixture:
  • (C.A.S. #105–59–9) Methyldiethanolamine.

The following biological materials consist of human, animal, and plant materials that are considered export controlled and will require a license to be exported to any country.

“Genetic element” – Includes, but is not limited to, chromosomes, genomes, plasmids, transposons, vectors, and inactivated organisms containing recoverable nucleic acid fragments, whether genetically modified or unmodified, or chemically synthesized in whole or in part. Nucleic acids from an inactivated organism, virus, or sample are considered to be “recoverable” if the inactivation and preparation of the material is intended or known to facilitate isolation, purification, amplification, detection, or identification of nucleic acids.

“Genetically modified organism” – Organisms in which the nucleic acid sequences have been created or altered by deliberate molecular manipulation.

Viruses

• African horse sickness virus
• African swine fever virus
• Andean potato latent virus (Potato Andean latent tymovirus)
• Andes virus
• [1]Avian influenza (AI) viruses1 identified as having high pathogenicity (HP), as follows:
  • AI viruses that have an intravenous pathogenicity index (IVPI) in 6-week-old chickens >1.2 or
  • AI viruses that cause at least 75% mortality in 4- to 8-week-old chickens infected IV.
• Blue tongue virus
• Chapare virus
• Chikungunya virus
• Choclo virus
• Classical swine fever (Hog cholera virus)
• Crimean-Congo hemorrhagic fever virus
• Dobrava-Belgrade virus
• Eastern equine encephalitis virus
• Ebola virus (including all members of the Ebolavirusgenus)
• Foot-and-mouth disease virus
• Goat pox virus
• Guanarito virus
• Hantaan virus
• Hendra virus (Equine morbillivirus)
• Japanese encephalitis virus
• Junin virus
• Kyasanur Forest disease virus
• Laguna Negra virus
• Lassa fever virus
• Louping ill virus
• Lujo virus
• Lumpy skin disease virus
• Lymphocytic choriomeningitis virus
• Machupo virus
• Marburg virus (including all members of the Marburgvirusgenus)
• Middle East respiratory syndrome-related coronavirus (MERS-related coronavirus)
• Monkeypox virus
• Murray Valley encephalitis virus
• Newcastle disease virus
• Nipah virus
• Omsk hemorrhagic fever virus
• Oropouche virus
• Peste des petits ruminants virus
• Porcine Teschovirus
• Potato spindle tuber viroid
• Powassan virus
• Rabies virus and all other members of the Lyssavirusgenus
• 1918 pandemic influenza virus – reconstructed replication competent forms containing any portion of the coding regions of all 8 gene segments.
• Rift Valley fever virus
• Rinderpest virus
• Rocio virus
• Sabia virus
• Seoul virus
• SARS-related coronavirus (SARS-CoV).
  • As per BIS guidance, SARS-CoV-2 is not yet included on this list.
• Sheep pox virus
• Sin Nombre virus
• Louis encephalitis virus
• Suid Herpesvirus 1 (Pseudorabies virus; Aujeszky’s disease)
• Swine vesicular disease virus
• Tickborne encephalitis virus (Far eastern subtype, formerly Russian Spring-Summer encephalitis virus). Tickborne encephalitis virus (Siberian subtype, formerly West Siberian virus)
• Variola virus
• Venezuelan equine encephalitis virus
• Vesicular stomatitis virus
• Western equine encephalitis virus
• Yellow fever virus

Biological Toxins and Subunits Thereof

• Abrin
• Aflatoxins
• Botulinum toxins
• Cholera toxin
• Clostridium perfringens alpha, beta 1, beta 2, epsilon and iota toxins
• Conotoxin
• Diacetoxyscirpenol toxin
• HT-2 toxin
• Microcystin (Cyanginosins)
• Modeccin toxin
• Ricin
• Saxitoxin
• Shiga toxin (shiga-like toxins, verotoxins, and verocytotoxins)
• Staphylococcus aureus enterotoxins, hemolysin alpha toxin, and toxic shock syndrome toxin (formerly Staphylococcus enterotoxin F)
• T-2 toxin
• Tetrodotoxin
• Viscumin (Viscum album lectin 1)
• Volkensin toxin

Bacterial and Rickettsial Agents

• Bacillus anthracis
• Brucella abortus
• Brucella melitensis
• Brucella suis
• Burkholderia mallei (formerly Pseudomonas mallei)
• Burkholderia pseudomallei (formerly Pseudomonas pseudomallei)
• Clavibacter michiganensissubspecies sepedonicus (Corynebacterium michiganensis subspecies sepedonicum or Corynebacterium sepedonicum)
• Chlamydia psittaci (formerly Chlamydophila psittaci)
• Clostridium argentinense (formerly Clostridium botulinum Type G), botulinum neurotoxin producing strains
• Clostridium baratii, botulinum neurotoxin producing strains
• Clostridium botulinum
• Clostridium butyricum, botulinum neurotoxin producing strains
• Clostridium perfringens,epsilon toxin producing types
• Coxiella burnetii
• Francisella tularensis
• Mycoplasma capricolum subspeciescapripneumoniae (“strain F38”)
• Mycoplasma mycoides subspecies mycoides SC (small colony, contagious bovine pleuropneumonia)
• Ralstonia solanacearum, race 3, biovar 2
• Rathayibacter toxicus
• Rickettsia prowazekii
• Salmonella entericasubspecies enterica serovar Typhi (Salmonella Typhi)
• Shiga toxin producing Escherichia coli(STEC) of serogroups:
  • O26, O45, O103, O104, O111, O121, O145, O157.
  • Other Shiga toxin producing serogroups (STEC strains include, among others, enterohemorrhagic coli (EHEC).
  • Verocytotoxin-producing E. coli (VTEC).
• Shigella dysenteriae
• Vibrio cholerae
• Xanthomonas albilineans
• Xanthomonas axonopodiscitri (Xanthomonas campestris citri A) (Xanthomonas campestris pv. citri)
• Xanthomonas oryzae
• Yersinia pestis

Fungi

• Coccidioides immitis
• Coccidioides posadasii
• Cochliobolus miyabeanus(Helminthosporium oryzae)
• Colletotrichium kahawae(Colletotrichium coffeanum virulans)
• Magnaporthe oryzae(Pyricularia oryzae)
• Microcyclus ulei(Dothidella ulei)
• Peronosclerospora philippinensis(Peronosclerospora sacchari)
• Phoma glycinicola(formerly Pyrenochaeta glycines)
• Puccinia graminisgraminis graminis / Puccina graminis ssp. graminis car. stakmanii (Puccinia graminis [syn. Puccinia graminis f.sp. tritici])
• Puccinia striiformis(Puccinia glumarum)
• Sclerophthora rayssiaezeae
• Synchytrium endobioticum
• Thecaphora solani
• Tilletia indica

Vaccines, immunotoxins, medical products, diagnostic and good testing kits

• Vaccines against any materials or items listed above.
• Immunotoxins containing Biological Toxins or Subunits Thereof.
• Medical products containing botulinum toxins listed under Biological Toxins or Subunits Thereof.
• Medical products containing Biological Toxins or Subunits Thereof.
• Diagnostic and food testing kits containing Biological Toxins or Subunits Thereof.